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Fig. 1 | Virology Journal

Fig. 1

From: Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies

Fig. 1

Mapping of NAI-treatment emergent HA mutations on the H1N1 HA1 trimer. The NAI-treatment emergent HA mutations emerged in the H1N1 HA1 domain (listed in Table 1) were mapped onto the H1 HA1 trimer crystal structure (PDB:3LZG) to determine if these substitutions occurred in previously identified H1N1 antigenic sites [17]. The trimeric HA structure is shown in gray (•). Epitopes described in the literature for H1N1 were colored black (•). NAI-treatment emergent HA1 mutations are colored yellow (•). Amino acids associated with the RBS are shown in red (•) and NAI-treatment emergent substitutions occurred within the RBS are shown in orange (•). Panel A, H1N1 top view and Panel B, H1N1 side view, rotated 60 degrees upward. Labelling of amino acid positions was limited to one monomer. Boxes and lines colored in red indicate substitutions that were selected for evaluation in the HI and MN assays. Boxes and lines colored in green indicate substitutions that were not evaluated in the HI and MN assays

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Virology Journal

ISSN: 1743-422X