Table 3 Odds ratio with 95% confidence interval for HPV16 viral load and total hrHPV viral load for total hrHPV copy number and titer
Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | |
|---|---|---|---|---|
HPV16 copy number | ||||
Range | 10.5–54.9 | 56.0–404.2 | 414.0–4772.9 | 4952.2–2.6E+ 6 |
Median | 23 | 131 | 1546 | 19,915 |
No of women with transient infection | 20 | 13 | 11 | 6 |
No of women with persistent infection | 32 | 39 | 41 | 45 |
Odds ratio, course of infection | NA | 1.9(0.8–4.4) | 2.3 (1.0–5.7) | 4.5 (1.7–13.9) |
OR, course of infection, p-value, fisher exact | NA | 0.206 | 0.085 | 0.003 |
No of women with CIN2+ | 14 | 23 | 30 | 26 |
No of women without CIN2+ | 38 | 29 | 22 | 25 |
Odds ratio, CIN2+ | NA | 2.1 (0.9⎯5.0) | 3.6 (1.6⎯8.5) | 2.8 (1.2⎯6.5) |
OR, CIN2+, p-value, fisher exact | NA | 0.101 | 0.003 | 0.016 |
HPV16 titer | ||||
Range | 8.8E-04 ⎯ 7.1E-02 | 8.0E-02 ⎯ 0.65 | 0.65 ⎯ 7.26 | 7.31 ⎯ 994.68 |
Median | 0.03 | 0.22 | 2.29 | 22.22 |
No of women with transient infection | 22 | 12 | 8 | 8 |
No of women with persistent infection | 40 | 40 | 44 | 43 |
Odds ratio, course of infection | NA | 2.4 (1.0–5.8) | 3.9 (1.6–10.7) | 3.9 (1.6–10.4) |
OR, course of infection, p-value, fisher exact | NA | 0.059 | 0.004 | 0.004 |
No of women with CIN2+ | 13 | 26 | 28 | 26 |
No of women without CIN2+ | 39 | 26 | 24 | 25 |
Odds ratio, CIN2+ | NA | 3.0 (1.30⎯6.98) | 3.4 (1.51⎯8.15) | 3.1 (1.35⎯7.29) |
OR, CIN2+, p-value, fisher exact | NA | 0.015 | 0.005 | 0.008 |
Total hrHPV copy numbers | ||||
Range | 10.2–50.4 | 50.7–281.9 | 286.2–2594.1 | 2619.5–3.9E+ 6 |
Median | 22.4 | 118.4 | 795.8 | 10,079.6 |
No of women with transient infection | 82 | 68 | 45 | 33 |
No of women with persistent infection | 86 | 99 | 122 | 133 |
Odds ratio, course of infection | NA | 1.4 (0.9–2.1) | 2.6 (1.7–4.1) | 3.9 (2.4–6.4) |
OR, course of infection, p-value, fisher exact | NA | 0.015 | 4.55E-05 | 2.28E-08 |
No of women with CIN2+ | 33 | 43 | 53 | 62 |
No of women without CIN2+ | 134 | 124 | 114 | 104 |
Odds ratio, CIN2+ | NA | 1.4 (0.8⎯2.4) | 1.9 (1.1⎯3.1) | 2.4 (1.5⎯4.0) |
OR, CIN2+, p-value, fisher exact | NA | 0.240 | 0.017 | 4.22E-04 |
Total hrHPV titer | ||||
Range | 7.7E-04 ⎯ 6.0E-02 | 6.0E-02 ⎯ 0.4 | 0.4 ⎯ 3.9 | 3.9 ⎯ 1243.2 |
Median | 0.02 | 0.15 | 1.12 | 17.5 |
No of women with transient infection | 88 | 56 | 40 | 44 |
No of women with persistent infection | 79 | 111 | 127 | 122 |
Odds ratio, course of infection | NA | 2.2 (1.4–3.4) | 3.5 (2.2–5.7) | 3.1(1.9–4.9) |
OR, course of infection, p-value, fisher exact | NA | 5.92E-04 | 9.53E-08 | 1.26E-06 |
No of women with CIN2+ | 27 | 53 | 60 | 51 |
No of women without CIN2+ | 140 | 114 | 107 | 115 |
Odds ratio, CIN2+ | NA | 2.4 (1.4⎯4.1) | 2.9 (1.7⎯4.9) | 2.3 (1.4⎯3.9) |
OR, CIN2+, p-value, fisher exact | NA | 1.26E-03 | 5.73E-05 | 1.89E-03 |