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Table 2 Median for type-specific hrHPV viral load and total hrHPV viral load and two-sided rank-based Spearman test with Bonferroni corrected p-values for the comparisons of hrHPV copy number and hrHPV titer in the primary screening and follow-up test between women with transient and persistent infection, with or without CIN2+ diagnosed during follow-up

From: HPV viral load in self-collected vaginal fluid samples as predictor for presence of cervical intraepithelial neoplasia

HPV type

16

18/45

31

33/52/58

35

39

51

56

59

Total

Viral Load

A. Baseline HPV self-sample test copy number

 Median

  Transient

71.6

84.7

109.2

53.2

1071.2

43.9

184.2

166.0

845.8

126

  Persistent

593.1

112.1

364.4

751.7

327.7

376.8

442.1

153.2

336.5

497

  CIN2+

866.2

92.6

438.4

688.8

13.4

140.4

9808.2

70.1

16,561.6

575

 Bonferroni-corrected p-values

  Transient vs. Persistent

1.42E-02

1

5.89E-02

9.72E-07

1

0.3513

1

1

1

1.34E-08

  Transient vs. CIN2+

5.33E-03

1

1.42E-01

1.82E-04

1

1

1

1

1

3.85E-07

  Persistent vs. CIN2+

1

1

1

1

1

1

1

1

1

1

Follow up self-sample

 Median

  Persistent

329.7

433.3

243.0

732.2

982.9

1289.5

1392.7

212.0

125.0

415.9

  CIN2+

945.7

84.4

131.7

534.7

429.9

626.2

4523.8

259.6

38,399.8

724.7

 q-values, Bonferroni-corrected p-values

  Persistent vs. CIN2+

7.11E-01

1

1

1

1

1

1

1

1

1

B. Baseline HPV self-sample test titer

 Median

  Transient

0.13

0.09

0.12

0.05

1.47

0.05

0.17

0.41

1.58

0.13

  Persistent

1.07

0.21

0.60

0.93

0.71

0.42

0.53

0.54

0.33

0.66

  CIN2+

1.10

0.07

0.43

0.79

0.01

0.13

6.39

0.05

2.64

0.68

 Bonferroni-corrected p-values

  Transient vs. Persistent

2.66E-02

1

0.23147

1.13E-04

1

1

1

1

1

5.82E-07

  Transient vs. CIN2+

1.17E-02

1

1

4.44E-03

1

1

1

1

1

4.73E-06

  Persistent vs. CIN2+

1

1

1

1

1

1

1

1

1

1

Follow-up self-sample

 Median

  Persistent

0.28

0.66

0.76

0.77

0.27

1.07

1.30

0.10

0.37

0.57

  CIN2+

1.92

0.25

0.17

1.22

1.12

0.94

4.30

0.11

16.22

1.33

 Bonferroni-corrected p-values

  Persistent vs. CIN2+

2.29E-03

1

1

1

1

1

1

1

1

0.14