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Table 2 Median for type-specific hrHPV viral load and total hrHPV viral load and two-sided rank-based Spearman test with Bonferroni corrected p-values for the comparisons of hrHPV copy number and hrHPV titer in the primary screening and follow-up test between women with transient and persistent infection, with or without CIN2+ diagnosed during follow-up

From: HPV viral load in self-collected vaginal fluid samples as predictor for presence of cervical intraepithelial neoplasia

HPV type1618/453133/52/583539515659Total
Viral Load
A. Baseline HPV self-sample test copy number
 Median
  Transient71.684.7109.253.21071.243.9184.2166.0845.8126
  Persistent593.1112.1364.4751.7327.7376.8442.1153.2336.5497
  CIN2+866.292.6438.4688.813.4140.49808.270.116,561.6575
 Bonferroni-corrected p-values
  Transient vs. Persistent1.42E-0215.89E-029.72E-0710.35131111.34E-08
  Transient vs. CIN2+5.33E-0311.42E-011.82E-04111113.85E-07
  Persistent vs. CIN2+1111111111
Follow up self-sample
 Median
  Persistent329.7433.3243.0732.2982.91289.51392.7212.0125.0415.9
  CIN2+945.784.4131.7534.7429.9626.24523.8259.638,399.8724.7
 q-values, Bonferroni-corrected p-values
  Persistent vs. CIN2+7.11E-01111111111
B. Baseline HPV self-sample test titer
 Median
  Transient0.130.090.120.051.470.050.170.411.580.13
  Persistent1.070.210.600.930.710.420.530.540.330.66
  CIN2+1.100.070.430.790.010.136.390.052.640.68
 Bonferroni-corrected p-values
  Transient vs. Persistent2.66E-0210.231471.13E-04111115.82E-07
  Transient vs. CIN2+1.17E-02114.44E-03111114.73E-06
  Persistent vs. CIN2+1111111111
Follow-up self-sample
 Median
  Persistent0.280.660.760.770.271.071.300.100.370.57
  CIN2+1.920.250.171.221.120.944.300.1116.221.33
 Bonferroni-corrected p-values
  Persistent vs. CIN2+2.29E-03111111110.14