Skip to main content

Table 4 Sensitivity, specificity, PPV, NPV and Youden index of HPV DNA assay, HPV E6/E7mRNA testing and p16/Ki-67 immunocytochemistry

From: Prognostic and diagnostic validity of p16/Ki-67, HPV E6/E7 mRNA, and HPV DNA in women with ASCUS: a follow-up study

Test

Sensitivity

Specificity

PPV

NPV

Youden index

(95% CI)

(95% CI)

(95% CI)

(95% CI)

DNA

100%

11.34%

6.52%

100%

11.34

(60.97, 100)

(6.45, 19.71)

(3.02, 13.51)

(74.12, 100)

 

E6/E7 mRNA

100%

44.33%

10.00%

100%

44.33

(60.97, 100)

(34.85, 54.24)

(4.67, 20.15)

(91.80, 100)

 

p16/Ki67

50%

75.26%

11.11%

96.05%

25.26

(18.76, 81.24)

(65.82, 82.77)

(3.85, 28.06)

(89.03, 98.65)

 
  1. PPV positive predictive value, NPV negative predictive value. Results in % with 95% confidence interval (95% CI). DNA: HPV DNA assay; E6/E7 mRNA: HPV E6/E7 mRNA testing; p16/Ki-67: p16/Ki-67 immunocytochemistry
Back to article page

Virology Journal

ISSN: 1743-422X