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Table 4 Sensitivity, specificity, PPV, NPV and Youden index of HPV DNA assay, HPV E6/E7mRNA testing and p16/Ki-67 immunocytochemistry

From: Prognostic and diagnostic validity of p16/Ki-67, HPV E6/E7 mRNA, and HPV DNA in women with ASCUS: a follow-up study

TestSensitivitySpecificityPPVNPVYouden index
(95% CI)(95% CI)(95% CI)(95% CI)
DNA100%11.34%6.52%100%11.34
(60.97, 100)(6.45, 19.71)(3.02, 13.51)(74.12, 100) 
E6/E7 mRNA100%44.33%10.00%100%44.33
(60.97, 100)(34.85, 54.24)(4.67, 20.15)(91.80, 100) 
p16/Ki6750%75.26%11.11%96.05%25.26
(18.76, 81.24)(65.82, 82.77)(3.85, 28.06)(89.03, 98.65) 
  1. PPV positive predictive value, NPV negative predictive value. Results in % with 95% confidence interval (95% CI). DNA: HPV DNA assay; E6/E7 mRNA: HPV E6/E7 mRNA testing; p16/Ki-67: p16/Ki-67 immunocytochemistry