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Table 3 The results of HPV E6/E7 mRNA expression levels in different levels of cervical lesion

From: Prognostic and diagnostic validity of p16/Ki-67, HPV E6/E7 mRNA, and HPV DNA in women with ASCUS: a follow-up study

Groupexpression levels (copies / ml)aAverage rankZ valuep value
No biopsy0(0–3254.10)   
Inflammation733.44(0–2222.60)   
CIN12738.75(0–10,702.87)   
CIN2+94,116.51 (16,207.12–182,555.36)   
CIN1-522.45(0–3841.54)49.60−3.4070.001
CIN2+94,116.51 (16,207.12–182,555.36)90.83  
  1. a Median of mRNA load, with 25th–75th percentile in parentheses; CIN: cervical intraepithelial neoplasia; CIN1-: The diagnoses of cytology and HPV DNA negative (no biopsy), cervical inflammation and CIN1 are referred as < CIN1(CIN1 -); CIN2+: the diagnoses of CIN2, CIN3 and carcinoma are referred as ≥ CIN2 (CIN2 +)