Table 1 The regulators of m6A in different viruses

HIV

METTL3/METTL14

Down

CD4⁺T cell

Rev

Suppress virus replication

[39]

ALKBH5

Down

CD4⁺T cell

Rev

Promote virus replication

YTHDF1–3

Up

CEM-SS T cell

–

Promote virus replication

[1, 39]

HeLa/CD4 cell

Gag

Suppress virus replication

[40]

EV71

METTL3

Down

Vero cells

RdRp 3D

Decrease in virus titer

[41]

FTO

Down

Vero cells

–

Promote in virus titer

YTHDF2/3

Down

Vero cells

–

Suppress virus replication

IAV

METTL3

Down

A549 cell

–

Suppress IAV replication

[42]

YTHDF2

Up

A549 cell

–

Promote IAV replication

KSHV

METTL3

Down

BCBL1 cell

ORF50

Suppress viral lytic replication

[43]

FTO

Down

BCBL1 cell

ORF50

Promote viral lytic replication

YTHDC1

Up

BCBL1 cell

ORF50

Promote ORF50 pre-mRNA splicing

YTHDF2

Down

iSLK.219/ iSLK.BAC16 cell

ORF50

Suppress transcription in ORF50

[44]

HBV

METTL3/14

Down

HepAD38 cell

–

Promote HBc/s protein expression and the half-life of pgRNA

[45]

FTO/ALKBH5/YTHDF2–3

Down

HepAD38 cell

–

Suppress HBc/s protein expression and the half-life of pgRNA

HCV

METTL3/14

Down

Huh7 cell

–

Enhance titer of HCV

[46]

FTO

Down

Huh7 cell

–

Decrease viral titer

YTHDF1–3

Up

Huh7 cell

–

Suppress HCV replication

HCC

METTL3

Down

Patient sample/ HepG2, Huh-7 and MHCC97L

SOCS2

Attenuate SOCS2 mRNA stability

[47]

METTL14

Down

Patient sample/ tumor tissues/ SMMC-7721, Hep3B and HepG2

miR-126

Regulate processing of miR-126 by DGCR8

[48]

CC

FTO

Up

Patient sample/ SiHa cell

–

Induce poor prognosis

[49, 50]

ZIKV

METTL3/14

Down

Vero cell

–

Increase viral titer

[51]

ALKBH5/FTO

Down

Vero cell

–

Decrease viral titer

YTHDF2

Up

Vero cell

–

Suppress ZIKV replication

SV40

METTL3

Down

BCS40 cell

–

Reduce SV40 replication

[52]

YTHDF2

Up

BCS40 cell

–

Enhance replication of SV40

EBV

METTL14

Up

LcLs and Akata cells

EBNA3C

Promote growth and proliferation of EBV-infected cells

[53]