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Fig. 1 | Virology Journal

Fig. 1

From: Association of N6-methyladenosine with viruses and related diseases

Fig. 1

A schematic model that illustrates the roles and regulation of m6A modification. m6A modification is regulated by “writers” “erasers” and “readers”. Writers and erasers are mainly located in the nucleus, where they modulate mRNAs splicing and nuclear export. YTHDC1 and HNRP2AB1 as nuclear readers also play a vital role in nuclear export. In the cytoplasm, YTHDF2 promotes degradation of mRNA; whereas YTHDF1/3, YTHDC2 and eIF3 participate in translation

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