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Table 4 Amino acid differences between the wild-type strain ZB and the mouse-adapted strain ZB-MA

From: Mouse-adapted H9N2 avian influenza virus causes systemic infection in mice

Proteins

AA site

ZB

ZB-MA

Avian H9N2

Human H9N2

pH1N1

Human H3N2

PB1

141a

T

A

T (100%)

T (100%)

T (100%)

T (100%)

708

P

L

P (100%)

P (100%)

P (100%)

P (100%)

PA

97c

T

I

T (100%)

T (100%)

T (99%)

T (100%)

N(1%)

489

S

C

C (97%)

C (100%)d

C (100%)

C (100%)

   

S(3%)

   

HA

27 (19)b

S

L

S (100%)

S (100%)

/

/

517 (508)

E

G

E (99%)

E (100%)

/

/

D (1%)

556 (544)

C

R

C (100%)

C (100%)

/

/

NA

377

V

I

V (89%)

I (11%)

V (44%)

I (56%)

/

V (48%)

T (47%)

I (5%)

M1

29

E

V

E (100%)

E (100%)

E (100%)

E (100%)

119

Y

H

Y (100%)

Y (100%)

Y (100%)

Y (100%)

157

S

A

A (89%)

A (100%)

S (100%)

S (100%)

   

S (11%)

   

158

H

Q

Q (94%)

Q (100%)

Q (100%)

Q (100%)

   

H (6%)

   

198

Q

H

Q (100%)

Q (100%)

Q (99%)

H (1%)

Q (100%)

219

I

V

V (87%)

V (40%)

I (100%)

I (100%)

I (13%)

I (60%)

222

Q

H

H (88%)

H (100%)

H (100%)

H (100%)

   

Q (12%)

   

239

A

T

A (100%)

A (100%)

A (100%)

T (97%)

A (2%)

M2

10

H

L

L (57.1%)

L (100%)

P (98%)

P (100%)

   

P (29.1%)

 

H (1%)

 

H (13.0%)

   

R (0.7%)

 

L (1%)

 

A (0.1%)

I (0.1%)

Y (0.1%)

16

E

G

E (85%)

G (99%)

E (87%)

G (99%)

   

V (12%)

 

G (13%)

E (1%)

   

G (3%)

   

27

I

V

V (92%)

V (100%)

V (100%)

V (97%)

   

I (5%)

  

I (1%)

   

M (3%)

  

T (1%)

      

A (1%)

32

V

I

I (83%)

I (100%)

I (100%)

I (100%)

   

V (17%)

   

37

H

R

H (100%)

H (100%)

H (100%)

H (100%)

NS1

74

D

N

D (99%)

D (100%)

S (85%)

D (100%)

D (14%)

H (1%)

A (1%)

NS2

75

E

V

E (99%)

E(100%)

E(100%)

E(100%)

K (0.7%)

D (0.3%)

  1. aH9 numbering
  2. bH3 numbering is in parentheses
  3. cThe substitutions also occurred in mice-adapted influenza viruses in the previous studies
  4. dThe substitutions which present more frequently in human influenza viruses than H9N2 AIVs was shown by bold and underline formats