Skip to main content

Advertisement

Table 4 Amino acid differences between the wild-type strain ZB and the mouse-adapted strain ZB-MA

From: Mouse-adapted H9N2 avian influenza virus causes systemic infection in mice

ProteinsAA siteZBZB-MAAvian H9N2Human H9N2pH1N1Human H3N2
PB1141aTAT (100%)T (100%)T (100%)T (100%)
708PLP (100%)P (100%)P (100%)P (100%)
PA97cTIT (100%)T (100%)T (99%)T (100%)
N(1%)
489SCC (97%)C (100%)dC (100%)C (100%)
   S(3%)   
HA27 (19)bSLS (100%)S (100%)//
517 (508)EGE (99%)E (100%)//
D (1%)
556 (544)CRC (100%)C (100%)//
NA377VIV (89%)
I (11%)
V (44%)
I (56%)
/V (48%)
T (47%)
I (5%)
M129EVE (100%)E (100%)E (100%)E (100%)
119YHY (100%)Y (100%)Y (100%)Y (100%)
157SAA (89%)A (100%)S (100%)S (100%)
   S (11%)   
158HQQ (94%)Q (100%)Q (100%)Q (100%)
   H (6%)   
198QHQ (100%)Q (100%)Q (99%)
H (1%)
Q (100%)
219IVV (87%)V (40%)I (100%)I (100%)
I (13%)I (60%)
222QHH (88%)H (100%)H (100%)H (100%)
   Q (12%)   
239ATA (100%)A (100%)A (100%)T (97%)
A (2%)
M210HLL (57.1%)L (100%)P (98%)P (100%)
   P (29.1%) H (1%) 
H (13.0%)
   R (0.7%) L (1%) 
A (0.1%)
I (0.1%)
Y (0.1%)
16EGE (85%)G (99%)E (87%)G (99%)
   V (12%) G (13%)E (1%)
   G (3%)   
27IVV (92%)V (100%)V (100%)V (97%)
   I (5%)  I (1%)
   M (3%)  T (1%)
      A (1%)
32VII (83%)I (100%)I (100%)I (100%)
   V (17%)   
37HRH (100%)H (100%)H (100%)H (100%)
NS174DND (99%)D (100%)S (85%)D (100%)
D (14%)
H (1%)
A (1%)
NS275EVE (99%)E(100%)E(100%)E(100%)
K (0.7%)
D (0.3%)
  1. aH9 numbering
  2. bH3 numbering is in parentheses
  3. cThe substitutions also occurred in mice-adapted influenza viruses in the previous studies
  4. dThe substitutions which present more frequently in human influenza viruses than H9N2 AIVs was shown by bold and underline formats