HPV infection | Test | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | |
---|---|---|---|---|---|---|
CINI+ | no | p16/Ki-67 | 88.64 (75.4–96.2) | 51.43 (34–68.6) | 69.9 (64.6–75) | 78.2 (68.5–85.7) |
HPV-16 and/or 58 | p16/Ki-67/HPV load | 90.8 (85.3–94.3) | 86.96 (66.4–97.2) | 98 (95.1–99.3) | 57.1 (47.8–62.5) | |
others | p16/Ki-67 | 81.36 (69.1–90.3) | 84.63 (65.1–95.6) | 92.3 (85.5–97.6) | 66.67 (58.1–73.9) | |
CINII+ | no | p16/Ki-67 | 94.12 (71.3–99.9) | 88.71 (78.1–95.3) | 69.6 (54.8–80) | 98.2 (92.2–100) |
HPV-16 and/or 58 | p16/Ki-67/HPV load | 88.89 (82.3–93.6) | 92.16 (81.1–97.8) | 95.8 (92.6–99.1) | 75.8 (67.6–82) | |
others | p16 | 94.59 (81.8–99.3) | 75 (60.4–86.4) | 74.5 (65.9–82.3) | 94.7 (86–99) | |
CINIII+ | no | p16/Ki-67 | 100 (47.8–100) | 90.54 (81.5–96.1) | 41.7 (26.7–44.4) | 100 (96.5–100) |
HPV-16 and/or 58 | p16/Ki-67/HPV load | 86.6 (78.2–92.7) | 77.53 (67.4–85.7) | 80.8 (75.6–85.4) | 84.1 (78.4–89.6) | |
others | p16/Ki-67 | 84.21 (60.4–96.6) | 96.97 (89.5–99.6) | 88.9 (72.4–97.5) | 95.5 (89.8–99) |