Table 2 P16 and Ki-67 positivity in histology categories stratified by age and HPV infection
Category | Cervicitis | CIN1 | CIN2 | CIN3 | cancer | Total |
|---|---|---|---|---|---|---|
HPV+ / < 30 | 4 | 6 | 3 | 4 | 0 | 17 |
% (p16+, Ki-67+, D+) | 0, 25, 0 | 50, 66.7, 16.7 | 100, 100, 100 | 75, 100, 75 | N/A | 52.9, 70.6, 41.2 |
HPV- / < 30 | 2 | 3 | 1 | 0 | 0 | 6 |
% (p16+, Ki-67+, D+) | 0, 50, 0 | 0, 66.7, 0 | 100, 100, 100 | N/A | N/A | 16.7, 66.7, 16.7 |
HPV+ / ≥30, < 45 | 18 | 28 | 27 | 51 | 9 | 133 |
% (p16+, Ki-67+, D+) | 11.1, 66.7, 11.1 | 35.7, 60.7, 25 | 81.5, 85.2, 70.4 | 86.3, 96.1, 84.3 | 100, 100, 100 | 64.7, 82.7, 59.4 |
HPV- / ≥30, < 45 | 13 | 13 | 9 | 1 | 1 | 37 |
% (p16+, Ki-67+, D+) | 0, 38.5, 0 | 0, 69.2, 0 | 76.9, 88.9, 76.9 | 100, 100, 100 | 100, 100, 100 | 27, 70.3, 27 |
HPV+ /≥45 | 27 | 16 | 26 | 32 | 20 | 121 |
% (p16+, Ki-67+, D+) | 11.1, 40.7, 7.4 | 37.5, 87.5, 37.5 | 80.8, 88.5, 73.1 | 96.9, 100, 96.9 | 95, 100, 95 | 66.1, 82.6, 63.6 |
HPV- / ≥45 | 20 | 11 | 2 | 1 | 2 | 36 |
% (p16+, Ki-67+, D+) | 20, 55, 20 | 27.3, 90.9, 27.3 | 50, 100, 50 | 100, 100, 100 | 100, 100, 100 | 30.6, 72.2, 30.6 |
Total | 84 | 77 | 68 | 89 | 32 | 350 |
% (p16+, Ki-67+, D+) | 10.7 48.8, 9.5 | 28.6, 72.7, 22.1 | 80.9, 88.2, 73.5 | 89.9, 97.8, 88.8 | 96.9, 100, 96.9 | 56.3, 78.9, 52.9 |