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Table 2 P16 and Ki-67 positivity in histology categories stratified by age and HPV infection

From: Combining HPV DNA load with p16/Ki-67 staining to detect cervical precancerous lesions and predict the progression of CIN1–2 lesions

Category Cervicitis CIN1 CIN2 CIN3 cancer Total
HPV+ / < 30 4 6 3 4 0 17
% (p16+, Ki-67+, D+) 0, 25, 0 50, 66.7, 16.7 100, 100, 100 75, 100, 75 N/A 52.9, 70.6, 41.2
HPV- / < 30 2 3 1 0 0 6
% (p16+, Ki-67+, D+) 0, 50, 0 0, 66.7, 0 100, 100, 100 N/A N/A 16.7, 66.7, 16.7
HPV+ / ≥30, < 45 18 28 27 51 9 133
% (p16+, Ki-67+, D+) 11.1, 66.7, 11.1 35.7, 60.7, 25 81.5, 85.2, 70.4 86.3, 96.1, 84.3 100, 100, 100 64.7, 82.7, 59.4
HPV- / ≥30, < 45 13 13 9 1 1 37
% (p16+, Ki-67+, D+) 0, 38.5, 0 0, 69.2, 0 76.9, 88.9, 76.9 100, 100, 100 100, 100, 100 27, 70.3, 27
HPV+ /≥45 27 16 26 32 20 121
% (p16+, Ki-67+, D+) 11.1, 40.7, 7.4 37.5, 87.5, 37.5 80.8, 88.5, 73.1 96.9, 100, 96.9 95, 100, 95 66.1, 82.6, 63.6
HPV- / ≥45 20 11 2 1 2 36
% (p16+, Ki-67+, D+) 20, 55, 20 27.3, 90.9, 27.3 50, 100, 50 100, 100, 100 100, 100, 100 30.6, 72.2, 30.6
Total 84 77 68 89 32 350
% (p16+, Ki-67+, D+) 10.7 48.8, 9.5 28.6, 72.7, 22.1 80.9, 88.2, 73.5 89.9, 97.8, 88.8 96.9, 100, 96.9 56.3, 78.9, 52.9