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Table 2 Susceptibility of highly pathogenic avian influenza rg006 H7N9 viruses to neuraminidase inhibitors

From: Highly pathogenic avian influenza H7N9 viruses with reduced susceptibility to neuraminidase inhibitors showed comparable replication capacity to their sensitive counterparts

Viruses Oseltamivir Zanamivir
Mean IC50a(nM) ± SD Fold changeb Mean IC50a(nM) ± SD Fold changeb
rg006-NA292R 1.24 ± 0.01 1 1.5 ± 0.10 1
rg006-NA119V 112.55 ± 17.25 90.77c 8.39 ± 0.44 5.59
rg006-NA292K 4571 ± 54.7 3686.29c 32.52 ± 4.35 21.68c
rg006-NA274Y 29.01 ± 0.18 23.40c 1.76 ± 0.13 1.17
rg006-NA246T 1.85 ± 0.11 1.49 16.46 ± 0.59 10.97c
A/Texas/12/2007 (H3N2 119E)d 0.12 ± 0.01 1 1.71 ± 0.63 1
A/Texas/12/2007 (H3N2 119 V)d 62.41 ± 2.16 520.08c 1.56 ± 0.55 0.91
  1. aIC50, half-maximal inhibitory concentration. The IC50 denotes the concentration of a NA inhibitor that reduces the NA activity by 50% relative to NA activity without the inhibitor
  2. bFold change relative to the mean IC50 of the wild-type NA protein. Fold-change values of each NA were interpreted using criteria established by the World Health Organization Influenza Antiviral Working Group
  3. cFold change > 10 (including reduced/highly reduced inhibition)
  4. dA/Texas/12/2007 (H3N2 119E) and A/Texas/12/2007 (H3N2 119 V), control virus