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Table 2 Susceptibility of highly pathogenic avian influenza rg006 H7N9 viruses to neuraminidase inhibitors

From: Highly pathogenic avian influenza H7N9 viruses with reduced susceptibility to neuraminidase inhibitors showed comparable replication capacity to their sensitive counterparts

Viruses

Oseltamivir

Zanamivir

Mean IC50a(nM) ± SD

Fold changeb

Mean IC50a(nM) ± SD

Fold changeb

rg006-NA292R

1.24 ± 0.01

1

1.5 ± 0.10

1

rg006-NA119V

112.55 ± 17.25

90.77c

8.39 ± 0.44

5.59

rg006-NA292K

4571 ± 54.7

3686.29c

32.52 ± 4.35

21.68c

rg006-NA274Y

29.01 ± 0.18

23.40c

1.76 ± 0.13

1.17

rg006-NA246T

1.85 ± 0.11

1.49

16.46 ± 0.59

10.97c

A/Texas/12/2007 (H3N2 119E)d

0.12 ± 0.01

1

1.71 ± 0.63

1

A/Texas/12/2007 (H3N2 119 V)d

62.41 ± 2.16

520.08c

1.56 ± 0.55

0.91

  1. aIC50, half-maximal inhibitory concentration. The IC50 denotes the concentration of a NA inhibitor that reduces the NA activity by 50% relative to NA activity without the inhibitor
  2. bFold change relative to the mean IC50 of the wild-type NA protein. Fold-change values of each NA were interpreted using criteria established by the World Health Organization Influenza Antiviral Working Group
  3. cFold change > 10 (including reduced/highly reduced inhibition)
  4. dA/Texas/12/2007 (H3N2 119E) and A/Texas/12/2007 (H3N2 119 V), control virus
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