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Table 1 Potential NAI resistance mutations in HPAI H7N9 virus from human cases

From: Highly pathogenic avian influenza H7N9 viruses with reduced susceptibility to neuraminidase inhibitors showed comparable replication capacity to their sensitive counterparts

Protein Site Function Amino Acid Human Cases
NA 115a(119b) Potential reducing the susceptibility of neuraminidase inhibitors E(GAA) 31
V(GTA) 1
243a (246b) A(GCC) 31
T(ACA) 1(fatal case)
271a (274b) H(CAT) 31
Y(TAT) 1(fatal case)
289a (292b) R(AGG) 26
R\K 1(fatal case)
K(AAG) 5(2fatalcases)