Highly pathogenic avian influenza H7N9 viruses with reduced susceptibility to neuraminidase inhibitors showed comparable replication capacity to their sensitive counterparts

Table 1 Potential NAI resistance mutations in HPAI H7N9 virus from human cases

Protein	Site	Function	Amino Acid	Human Cases
NA	115^a(119^b)	Potential reducing the susceptibility of neuraminidase inhibitors	E(GAA)	31
	115^a(119^b)		V(GTA)	1
	243^a (246^b)		A(GCC)	31
	243^a (246^b)		T(ACA)	1(fatal case)
	271^a (274^b)		H(CAT)	31
	271^a (274^b)		Y(TAT)	1(fatal case)
	289^a (292^b)		R(AGG)	26
			R\K	1(fatal case)
			K(AAG)	5(2fatalcases)

ISSN: 1743-422X