Skip to main content

Advertisement

Table 6 Genotype and allele frequencies of IL-β, IL17, IL10 and IL28 in influenza A (H1N1) and ILI groups

From: Association of polymorphisms in inflammatory cytokines encoding genes with severe cases of influenza A/H1N1 and B in an Iranian population

Gene and genotype/ Allele Flu A (H1N1) (%) ILI (%) Crude p value OR (95% CI) Adjusted P value
IL-1β; rs16944
 AA 6(20) 24(80)    
 GA 44(39.6) 67(60.4) .057   .185
 GG 0(0) 4(100)    
 GG vs. GA/AA 0(0) 50(35.5) 4(100) 91(64.5) .299 .000 (.000- NA) .999
 AA vs. GG/GA 6(20) 44(38.3) 24 (80) 71(61.7) .061 .295 (.103–.845) .023
 A 56 (56) 115 (60) .456 1.205(.738–1.967)  
 G 44 (44) 75 (39)    
IL-17;rs2275913
 AA 3(25) 9(75)    
 AG 16(22.9) 54(77.1) .007*   .011*
 GG 30(48.4) 32(51.6)    
 GG vs. GA/AA 30(48.4) 19(23.2) 32(51.6) 63(76.8) .002* 3.072 (1.461–6.461) .003*
 AA vs. AG/GG 3(25) 46(34.8) 9(75) 86(65.2) .491 .635 (.154–2.621) .530
 A 22 72 .008* 2.108(1.207–3.682)  
 G 76 118    
IL-10; rs1800872
 GG 3(42.9) 4(57.1) .851   
 TG 44(36.4) 77(63.6)    .575
 TT 3(30) 7(70)    
 TT vs. GG/TG 3(30) 47(36.7) 7(70) 81(63.3) .670 .774 (.183–3.277) .728
 GG vs. TG/TT 3(42.9) 47(35.9) 4(57.1) 84(64.1) .704 .810 (.165–3.974) .795
 T 50 91 .785 1.071(.655–1.749)  
 G 50 85    
IL-28; rs8099917
 GG 2(33.3) 4(66.7)    
 GT 28(36.8) 48(63.2) .863   .683
 TT 20(31.7) 43(68.3)    
 TT vs. GG/GT 20(31.7) 30(36.6) 43(68.3) 52(63.4) .543 .658 (.316–1.372) .264
 GG vs. GT/TT 2(33.3) 48(34.5) 4(66.7) 91(65.5) 1.000 1.228 (.206–7.323) .821
T 68 134 .656 1.126(.667–1.900)  
G 32 56    
  1. OR Odds ratio, CI Confidence interval (calculated by logistic regression model)
  2. p value is significant