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Fig. 1 | Virology Journal

Fig. 1

From: The interaction of hepatitis B virus with the ubiquitin proteasome system in viral replication and associated pathogenesis

Fig. 1

The mechanisms associated with the UPS in HBV replication. The UPS modulates the replication of the HBV via the regulation of viral proteins, the viral life cycle, and innate immune response. Several components of the UPS, such as P53 and Id-1, could repress viral replication through proteasome-dependent degradation of HBV proteins, including HBx, HBc, and Pol. However, some specific proteins interact with HBV proteins to inhibit the degradation of viral proteins. The UPS participates in different steps of the viral life cycle, including the stability of cccDNA, transcription and maturation, by interacting with HBx or HBc. Many components of the UPS participate in the innate immune response to inhibit viral replication. HBV proteins, such as HBx and Pol, promote the replication of the virus via regulating the ubiquitination of proteins associated with the innate immune response. PRRs: pattern recognition receptors. ISGs: IFN stimulated genes

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