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Table 2 Prediction programs showing membrane topologies of four different CoV E proteins with predicted locations of N- and C-termini, and TMDs. Prediction programs used: TM Pred, HMMTop, TMHMM 2.0, MEMSAT3, and MEMSAT-SVM [96,97,98,99,100]. Taken from Ruch and Machamer [41]

From: Coronavirus envelope protein: current knowledge

Prediction Program IBV E MHV E SARS E TGEV E
N C TMDs N C TMDs N C TMDs N C TMDs
TM Pred lumen lumen 2 lumen cyto 1 lumen cyto 1 lumen cyto 1
HMMTop lumen lumen 2 cyto cyto 2 lumen cyto 1 cyto cyto 2
TMHMM 2.0 lumen lumen 2 lumen cyto 1 cyto lumen 1 lumen cyto 1
MEMSAT-SVM lumen lumen 2 lumen lumen 2 lumen lumen 2 cyto lumen 1
MEMSAT3 cyto cyto 2 lumen cyto 1 lumen lumen 2 lumen cyto 1