Fig. 6
From: The tree shrew is a promising model for the study of influenza B virus infection
Inoculation of BALB/c mice with influenza B viruses causes inflammation in tissues of the respiratory tract. mRNA expression of IL-6 (a), IL-8 (b), IL-10 (c), IP-10 (d), TNF-α (e) and TGF-β (f) mRNA were increased at 2, 4 and 6 days post inoculation (DPI) in tissues of the respiratory tracts of mice inoculated with influenza B virus. The Yamagata strain B/Guangzhou/12/2016 elicited greater increases in the expression of IL-6 at two days post inoculation (DPI) (a), IL-10 at two and six DPI (c), IP-10 at all time points (d) and TNF-α at 6DPI (e). mRNA expression was detected via real-time PCR (SYBR Green) using GAPDH expression as a control. Fold changes are in comparison to uninoculated animals. Mice were inoculated with either Yamagata strain B/Guangzhou/12/2016 (Y12) or Victoria strain B/Guangzhou/0215/2012 (V0215)