Fig. 1

Bayesian inference of phylogenetic relationships of DENV-2 strains based on the envelope gene. The best nucleotide substitution model was GTR + I + G. Colombian strains sequenced in the present study belonging to Lineage 1 and Lineage 2 were labeled with orange triangles and blue circles, respectively. Amino acid changes in the envelope protein were mapped and depicted according to the occurrence as unique (red), convergences (blue) and reversions (green). Sequence labels included the GenBank accession number, followed by the strain name (and department in the case of Colombia), the two-letter country code (e.g. CO for Colombia, VE for Venezuela, PE for Peru, etc.) and the year of isolation