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Table 5 Characteristics of patients in the low HBV viral load group according to Sp1 and the G2765A substitution

From: A substitution in the pre-S1 promoter region is associated with the viral regulation of hepatitis B virus

   Sp1 G2765A
Wild type (n = 12) Substitution (n = 12) p Substitution (n = 8) p
Male (n (%)) 4 (33.3%) 9 (75.0%) 0.1 6 (75.0%) 0.170
Age (years) 53.9 (35–81) 58.2 (32–74) 0.522 63.4 (46–74) 0.150
HBV DNA (log IU/ml) 3.9 (1.3–4.4) 3.2 (1.3–3.5) 0.061 2.2 (1.3–3.0) 0.040
HBsAg (IU/ml) 4129 (8.61–18,268) 4483 (37.7–19,986) 0.525 2007 (37.7–6670) 0.340
HBeAg positive (n (%)) 0 (0%) 0 (0%) > 0.999 0 (0%) > 0.999
HBeAb positive (n (%)) 12 (100%) 12 (100%) > 0.999 8 (100%) > 0.999
AST (U/L) 26.8 (19–50) 22.0 (11–40) 0.074 19.0 (11–24) 0.011
ALT (U/L) 31.9 (14–90) 20.2 (11–40) 0.235 18.8 (10–27) 0.162
Platelet count (104/μl) 17.7 (13.9–22.5) 17.4 (10.9–22.6) 0.921 17.5 (10.9–22.6) 0.955
  1. Abbreviations: HBV hepatitis B virus, HBsAg hepatitis B surface antigen, HBeAg hepatitis B e antigen, HBeAb hepatitis B e antibody, AST aspartate transaminase, ALT alanine transaminase