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Table 3 G2765A substitution ratios determined by TA cloning or next-generation sequencing

From: A substitution in the pre-S1 promoter region is associated with the viral regulation of hepatitis B virus

TA cloninga Substitution percentage NGSa Substitution percentage
1/15 6.67% 44/6155 0.71%
0/15 0.00% 1/3955 0.03%
0/15 0.00% 10/5327 0.19%
9/15 60.00% 4866/8081 60.22%
0/16 0.00% 7/10409 0.07%
0/15 0.00% 2/7304 0.03%
0/15 0.00% 9/6662 0.14%
1/25 4.00% 22/6258 0.35%
1/16 6.25% 49/1643 2.98%
0/15 0.00% 1/2740 0.04%
  1. These samples were selected from high HBV viral load (8.2–7.2 log IU/ml) patients
  2. a Number of samples with the G2765A substitution/total number of samples
  3. Abbreviation: NGS next-generation sequencing