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Table 2 Characteristics of patients with pre-S1 promoter mutant or wild-type HBV

From: A substitution in the pre-S1 promoter region is associated with the viral regulation of hepatitis B virus

  All (n = 35) Wild type (n = 22) Mutation (n = 13) p
Male (n (%)) 20 (57.1%) 10 (45.5%) 10 (76.9%) 0.089
Age (years) 51.7 (15–81) 49.2 (15–81) 55.9 (29–74) 0.432
HBV DNA (log IU/ml) 5.11 (1.3–8.2) 5.22 (1.3–8.2) 2.86 (1.3–8.2) 0.003
HBsAg (IU/ml) 13,499 (8.61–151,233) 17,788 (8.61–151,233) 5634 (37.7–19,986) 0.094
HBeAg positive (n (%)) 11 (31.4%) 10 (45.5%) 1 (7.7%) 0.027
HBeAb positive (n (%)) 24 (68.6%) 12 (54.5%) 12 (92.3%) 0.027
AST (U/L) 34.5 (11–204) 41.4 (16–204) 22.7 (11–40) 0.035
ALT (U/L) 43.8 (10–425) 56.5 (14–425) 22.4 (10–49) 0.127
Platelet count (104/μl) 18.5 (10.9–24.2) 18.8 (13.9–23.9) 18.0 (10.9–24.2) 0.705
  1. Abbreviations: HBV hepatitis B virus, HBsAg hepatitis B surface antigen, HBeAg hepatitis B e antigen, HBeAb hepatitis B e antibody, AST aspartate transaminase, ALT alanine transaminase