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Table 4 Nucleotide variations and amino acid substitutions in HPV-58 E6 and E7

From: Identification of variants and therapeutic epitopes in HPV-33/HPV-58 E6 and E7 in Southwest China

HPV-58 E6 E7
S. No. M1 M2 M3 M4 M5 M6 M7 M8 M1 M2 M3 M4 M5 M6 M7 M8 M9 M10 M11 M12 M13
Position 187 203 259 307 367 388 395 543 599 632 694 726 744 755 760 761 763 793 798 801 803
Ref C G A C C A T G G C G T T C G G A A C C T
Normal
 A A A A A A A A A
 T T T T T
 G G G G G
 C C C C C C
Frequency 7 1 2 237 1 111 1 16 13 74 162 7 319 26 74 163 26 1 1 1 82
% of Samples 1.73 0.25 0.49 58.52 0.25 27.41 0.25 3.95 3.21 18.27 40.00 1.73 78.76 6.42 18.27 40.25 6.42 0.25 0.25 0.25 20.25
Amino acid Mutation E32Q D86E K93N R145K R9K T20I G41R T61N G63S G63D T64A T74A D76E V77A
Secondary structure S C S H C C C C C C C C S C C C C H H H H
  1. Note: In the row of ‘S. No’, M refers to mutation. The row of ‘Ref’ refers to the base in reference sequence. In the row of ‘Secondary structure’, C refers to coil, S refers to β-sheet, and H refers to α-helix