Table 4 Nucleotide variations and amino acid substitutions in HPV-58 E6 and E7
From: Identification of variants and therapeutic epitopes in HPV-33/HPV-58 E6 and E7 in Southwest China
HPV-58 | E6 | E7 | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
S. No. | M1 | M2 | M3 | M4 | M5 | M6 | M7 | M8 | M1 | M2 | M3 | M4 | M5 | M6 | M7 | M8 | M9 | M10 | M11 | M12 | M13 |
Position | 187 | 203 | 259 | 307 | 367 | 388 | 395 | 543 | 599 | 632 | 694 | 726 | 744 | 755 | 760 | 761 | 763 | 793 | 798 | 801 | 803 |
Ref | C | G | A | C | C | A | T | G | G | C | G | T | T | C | G | G | A | A | C | C | T |
Normal | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
 A | – | – | – | – | A | – | – | A | A | – | A | – | – | A | A | A | – | – | – | A | – |
 T | T | – | – | T | – | – | – | – | – | T | – | – | – | – | – | – | – | – | T | – | – |
 G | – | – | G | – | – | – | – | – | – | – | – | – | G | – | – | – | G | G | – | – | – |
 C | – | C | – | – | – | C | C | – | – | – | – | C | – | – | – | – | – | – | – | – | C |
Frequency | 7 | 1 | 2 | 237 | 1 | 111 | 1 | 16 | 13 | 74 | 162 | 7 | 319 | 26 | 74 | 163 | 26 | 1 | 1 | 1 | 82 |
% of Samples | 1.73 | 0.25 | 0.49 | 58.52 | 0.25 | 27.41 | 0.25 | 3.95 | 3.21 | 18.27 | 40.00 | 1.73 | 78.76 | 6.42 | 18.27 | 40.25 | 6.42 | 0.25 | 0.25 | 0.25 | 20.25 |
Amino acid Mutation | – | E32Q | – | – | D86E | K93N | – | R145K | R9K | T20I | G41R | – | – | T61N | G63S | G63D | T64A | T74A | – | D76E | V77A |
Secondary structure | S | C | S | H | C | C | C | C | C | C | C | C | S | C | C | C | C | H | H | H | H |