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Table 3 Nucleotide variations and amino acid substitutions in HPV-33 E6 and E7

From: Identification of variants and therapeutic epitopes in HPV-33/HPV-58 E6 and E7 in Southwest China

HPV-33 E6 E7
S. No. M1 M2 M3 M4 M5 M6 M7 M8 M1 M2 M3 M4
Position 213 273 329 364 387 446 542 549 658 706 706 862
Ref A A G A A A G T G C C A
Normal
 A A
 T T T T
 G G G C
 C C C C C C
Frequency 42 17 7 16 42 16 33 25 16 36 27 19
% of Samples 19.44 7.87 3.24 7.41 19.44 7.41 15.28 11.57 7.4 16.67 12.5 8.8
Amino acid Mutation K35N S74T N86H K93N Q113R R145I S29T A45V A45E Q97L
Secondary structure C S H C C H C C C C C C
  1. Note: In the row of ‘S. No’, M refers to mutation. The row of ‘Ref’ refers to the base in reference sequence. In the row of ‘Secondary structure’, C refers to coil, S refers to β-sheet, and H refers to α-helix