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Table 3 Multivariate and univariate analyses of factors associated with HBeAg seroconversion at 24 weeks posttreatment

From: Serum hepatitis B virus RNA levels as a predictor of HBeAg seroconversion during treatment with peginterferon alfa-2a

Variables Univariate analysis Multivariate analysis
Odd ratio 95% confidence interval P value Odd ratio 95% confidence interval P value
Sex (male) 0.810 (0.241–2.651) 0.715    
Age (years) 0.896 (0.818–0.981) 0.018 0.687 (0.384–0.850) 0.040
ALT (U/L) × ULN at baseline 1.315 (0.977–1.768) 0.071 1.660 (1.097–2.875) 0.041
AST (U/L) × ULN at baseline 1.298 (0.849–1.501) 0.087    
Baseline HBV DNA ≤ 30,000,000 copies/mL copies/mL 1.636 (0.542–4.937) 0.382    
Baseline HBV RNA ≤ 200,000 copies/mL 3.818 (1.228–12.871) 0.021 1.841 (1.175–3.708) 0.008
Baseline HBsAg ≤8000 IU/mL 6.001 (1.787–20.150) 0.004 3.791 (1.969–25.358) 0.003
HBV DNA ≤ 200,000 copies/mL at week 12 3.429 (0.969–12.131) 0.056    
HBV RNA ≤ 3000 copies/mL at week 12 5.357 (1.605–17.879) 0.006 12.458 (3.969–80.494) 0.039
HBsAg ≤4000 IU/mL at week 12 7.363 (2.150–25.223) 0.001    
HBV DNA ≤ 30,000 copies/mL at week 24 12.681 (1.783–60.873) 0.012    
HBV RNA ≤ 1000 copies/mL at week 24 6.500 (1.915–22.051) 0.003    
HBsAg ≤2000 IU/mL at week 24 7.519 (2.232–25.316) 0.001 3.297 (1.346–21.391) 0.031
  1. ALT alanine aminotransferase, AST aspartate aminotransferase, HBsAg hepatitis B surface antigen, HBV DNA hepatitis B deoxyribonucleic acid, HBV RNA hepatitis B ribonucleic acid