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Fig. 3 | Virology Journal

Fig. 3

From: The Epstein-Barr virus EBNA1 protein modulates the alternative splicing of cellular genes

Fig. 3

Bioinformatic analysis of genes that have their splicing changed in EBNA1-expressing cells; (a) Pie chart of the different protein class for the genes with EBNA1-driven change in splicing. A wide range of classes are present, showing that EBNA1 does not seem to impact the splicing of one particular class of protein; (b) String network of the 89 genes that have their splicing modified in EBNA1-expressing cells. A small network of interacting protein including SYK, BMP4, PAX2 and RUNX2 is present (p = 0.0324); (c) Gene Ontology analysis using DAVID reveals enrichment in KEGG pathways linked to adhesion, signaling and cancer mainly. Molecular function also reveals this enrichment, as seems by GO terms linked to receptor, cytoskeletal and cell adhesion binding, and cell metabolism

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