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Fig. 2 | Virology Journal

Fig. 2

From: The Epstein-Barr virus EBNA1 protein modulates the alternative splicing of cellular genes

Fig. 2

High-throughput RT-PCR shows expression of EBNA1 protein alters normal splicing of cellular genes implicated in cancer; (a) Respective ΔPSI values for the 89 genes that have their splicing modified in EBNA1-expressing cells. A cutoff of at least 10 of ΔPSI between control and EBNA1-expressing cells was used to identify changes in AS; (b) Relevant examples of splicing changes in EBNA1 expressing cells. The CCDC62, LPPR5 and NTRK2 transcripts all show important shift in the ASEs when EBNA1 is expressed. Red arrows indicate the short form for the ASE analyzed; black arrows indicate the long one

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