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Table 1 Subjective scale for semi-quantitative analysis of the degree of liver injury based on histopathological alterations

From: Efficacy of geraniin on dengue virus type-2 infected BALB/c mice

Histopathological alterations 0 1 2 3
Hydropic degeneration (hepatocyte swelling) None Mild (small area, ground glass appearance of hepatocytes) Moderate (larger area, ground glass appearance of hepatocytes) Diffuse (feathery appearance of hepatocytes)
Necrosis & haemorrhage None Mild (no haemorrhage) Moderate (small area, focal) Severe (large area, multifocal)
Venous outflow congestion (dilatation of sinusoids) None Mild (slight) Moderate (focal) Severe (diffuse)
Steatosis None Mild (small area, microsteatosis) Moderate (larger zones, micro- and macrosteatosis) Severe (diffuse micro- and macrosteatosis)
Pyknotic nucleus None Mild Moderate Severe
  1. Liver sections from six replicates mice (n = 6) were evaluated using a scale ranging from 0 to 3 (0 = none, 1 = mild, 2 = moderate and 3 = severe) according to the degree of hydropic change (hepatocyte swelling); necrosis and haemorrhage; venous outflow congestion (dilatation of sinusoids); steatosis; and pyknotic nucleus