Table 1 Main characteristics of the studies and patients enrolled in this comprehensive analysis
Study | Study design | Study period | Regimen | N | SVR12 (%) | Mean ± SD (Age, year) | Male (%) | Cirrhosis (Yes|No) | TN|TE | GT1|GT4 |
|---|---|---|---|---|---|---|---|---|---|---|
Rios (2018) | observational study | 2014.12–2016.8 | OPr ± D ± R | 440 | 420 (95.5) | 51.0 ± 1.2 | NA | 101|339 | NA | 299|125 |
Pineda (2018) | cohort | 2015.3–2017.1 | OPrD±R | 182 | 172 (94.5) | 51.0 ± 1.2 | 151 (82.9) | 69|113 | 101|81 | GT1 |
Massimo (2017) | cohort | NA | OPrD±R | 210 | 203 (96.7) | 53.0 ± 7.8 | 157 (74.8) | 23|187 | 96|114 | GT1 |
Rockstroh (2017) | clinical trial | 2015.7–2015.12 | OPrD±R | 228 | 221 (96.9) | 50.0 ± 7.2 | 171 (75.0) | 23|205 | 151|76 | 200|28 |
Bhattacharya (2017) | observational cohort | 2016.4 | OPrD±R | 89 | 79 (88.8) | 61.4 ± 6.1 | 89 (100) | 14|75 | 79|10 | GT1 |
Sulkowski (2015) | clinical trial | 2013.9–2014.8 | OPrD+R | 63 | 58 (92.1) | 50.9 ± 7.2 | 58 (92.0) | NA | 42|21 | GT1 |
Montes (2017) | observational study | 2015.4–2015.12 | OPr ± D ± R | 88 | 87 (98.9) | 51.4 ± 1.0 | 67 (76.1) | NA | NA | NA |
Wyles (2017) | clinical trial | 2014.12–2015.7 | OPrD+R | 22 | 22 (100.0) | NA | 17 (77.3) | 3|19 | 19|3 | GT1 |
Steiner (2017) | cohort | 2016.4 | OPr ± D | 14 | 14 (100.0) | 41.9 ± 3.2 | 9 (66.7) | NA | NA | 11|3 |
Milazzo (2017) | observational study | 2014.12–2015.12 | OPrD±R | 22 | 20 (90.9) | 51.5 ± 3.1 | NA | NA | NA | GT1 |