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Fig. 2. | Virology Journal

Fig. 2.

From: Multiple amino acid substitutions involved in the adaption of three avian-origin H7N9 influenza viruses in mice

Fig. 2.

Titers of virus in different tissues of the parental and mouse-adapted H7N9 viruses in mice. Groups of 6 6-week-old female BALB/C mice were inoculated i.n. with 106 EID50 (50 μl) of H7N9-53, H7N9-53 MA, H7N9-MCX, H7N9-MCX MA, H7N9-ZSM, H7N9-ZSM MA and PBS, respectively. 3 dpi, 3 mice were euthanized to collect hearts, liver, spleens, lungs, kidneys and brains for determination of virus titers by EID50. The remaining 3 mice were euthanized for lung viral loads by 5 dpi. a Lung viral loads of mice inoculated with H7N9 virus at 3 and 5 dpi. b Viral distribution of H7N9 virus in different tissues. The limit of virus detection is indicated by a dotted line.

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Virology Journal

ISSN: 1743-422X