Fig. 3

DDR characterization of the 3D in vitro reconstructed E6E7 HPV16 infected epithelia. Double immunofluorescent and western blot (B) analysis of the DNA break sensors. γH2A.X (in red) and 53BP1 (in green) in control normal (A) and E6E7HPV16 infected epithelia (C-C′-C″). γH2A.X and 53BP1 are expressed in HPV infected 3D samples