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Fig. 7 | Virology Journal

Fig. 7

From: Porcine reproductive and respiratory syndrome virus inhibits MARC-145 proliferation via inducing apoptosis and G2/M arrest by activation of Chk/Cdc25C and p53/p21 pathway

Fig. 7

PRRSV infection significantly induces Chk1 expression and phosphorylation of Chk1. Lysates from mock- or PRRSV-infected MARC-145 cells were prepared at the indicated time points and were processed for western blot with specific antibodies against Chk1 and phospho-Chk1 (Ser345). MARC-145 cells treated with 50 ng/mL Noco. for 16 h served as a positive control (left). Phosphorylated Chk1 and Chk1 protein levels were quantitatively analyzed and compared with GAPDH expression levels using Image J(right). * indicates p < 0.05, ** indicates p < 0.01, *** indicates p < 0.001

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