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Fig. 10 | Virology Journal

Fig. 10

From: Porcine reproductive and respiratory syndrome virus inhibits MARC-145 proliferation via inducing apoptosis and G2/M arrest by activation of Chk/Cdc25C and p53/p21 pathway

Fig. 10

Proposed mechanisms of PRRSV-induced G2/M cell cycle arrest in MARC-145 cells. One the one hand, PRRSV infection activates Chk1, leading to cytoplasmic accumulation of Cdc25C and increasing of Cdc25C phosphorylation(Ser216) which is an inhibitory site of Cdc25C, therefore results in inhibition of Cdc25C activity. Inactivated Cdc25C and increased Wee1 and Myt1 expression promote downstream Cdc2 inhibitory phosphorylation(Tyr15) in the nucleus and consequently reduces the activity Cdc2-cyclinB1 complex. On the other hand, PRRSV infection activates p53/p21 signaling pathway which also inhibits the activity of Cdc2-cyclinB1 complex. The activity inhibition of Cdc2-cyclinB1 complex leads to G2/M cell cycle arrest in MARC-145 cells

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