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Table 3 Overall agreement, lower and upper confidence bound, and the KAPPA value of each flourescent channel per run

From: Validation of intra- and inter-laboratory reproducibility of the Xpert HPV assay according to the international guidelines for cervical cancer screening

  Agreement 95% CI Kappa Kappa 95% CI
Lower bound Upper bound Lower bound Upper bound
Intra-laboratory run 1versusIntra-laboratory run 2
 Fluorescent channel 1 99.4% 98.8% 100% 0.99 97.0% 100%
 Fluorescent channel 2 99.6% 99.1% 100% 0.99 97.8% 100%
 Fluorescent channel 3 98.0% 96.8% 99.2% 0.95 92.4% 98.2%
 Fluorescent channel 4 99.2% 98.5% 100% 0.98 96.3% 100%
 Fluorescent channel 5 98.8% 97.9% 99.8% 0.97 95.0% 99.4%
Intra-laboratory run 1 versusInter-laboratory (Ghent)
 Fluorescent channel 1 99.6% 99.1% 100% 0.99 97.8% 100%
 Fluorescent channel 2 99.6% 99.1% 100% 0.99 97.8% 100%
 Fluorescent channel 3 98.8% 97.9% 99.8% 0.97 94.9% 99.4%
 Fluorescent channel 4 99.2% 98.5% 100% 0.98 96.3% 100%
 Fluorescent channel 5 98.6% 97.6% 99.6% 0.97 94.3% 99.1%
Intra-laboratory run 2 versusInter-laboratory (Ghent)
 Fluorescent channel 1 99.4% 98.8% 100% 0.99 97.0% 100%
 Fluorescent channel 2 100% 100% 100% 1.00 100% 100%
 Fluorescent channel 3 98.8% 97.9% 99.8% 0.97 95.0% 99.4%
 Fluorescent channel 4 99.2% 98.5% 100% 0.98 96.3% 100%
 Fluorescent channel 5 99.8% 99.4% 100% 1.00 98.6% 10%
  1. CI Confidence interval, Fluorescent channel FC 1 detects HPV16, FC2 detects HPV18 and HPV45, FC3 detects HPV31,33,35,52,58, FC4 detects HPV51,59, FC5 detects HPV 39,56,66,68