Validation of intra- and inter-laboratory reproducibility of the Xpert HPV assay according to the international guidelines for cervical cancer screening

Table 1 Intra and inter laboratory reproducibility

Intra-laboratory reproducibility^a
	Xpert HPV – AML Run 2		Total
Xpert HPV –AML Run 1	Negative	Positive
Negative	353	4	357
Positive	12	141	153
Total	365	145	510
Inter-laboratory agreement^b
	Xpert HPV UZ Ghent		Total
Xpert HPV –AML Run 1	Negative	Positive
Negative	356	1	357
Positive	10	143	153
Total	366	144	510
Inter-laboratory agreement^c
	Xpert HPV UZ Ghent		Total
Xpert HPV –AML Run 2	Negative	Positive
Negative	154	3	357
Positive	4	149	153
Total	157	153	510

^aThe overall HPV test agreement 96.9% (95% CI, 95.0–98.2%) KAPPA value of 0.925 (95% CI 0.888–0.961)
^bThe overall HPV test agreement 97.8% (95% CI, 96.2–98.9%) KAPPA value of 0.948 (95% CI 0.917–0.978)
^cThe overall HPV test agreement 98.6% (95% CI, 97.6–99.6%) KAPPA value of 0.967 (95% CI 0.943–0.991)

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