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Table 2 Comparative analysis of HCPs present in viruses and ECVs

From: Mass spectrometry-based investigation of measles and mumps virus proteome

Protein MMa/kDa UC HIC IAC
E1 E2
ECV MUV MEV ECV MUV MEV ECV MUV MEV ECV MUV
 heparan sulphate proteoglycan 469          +   
 filamin 280 +   +         
 fibronectin 262 + + + + + + + + +   
 clathrin heavy chain (HC) 192 +   +         
 vinculin 124 +           
 integrin α III 117   2D      +    +  
 integrin α V 116 + +      +    +  
 Na+/K+ ATPase subunit 1 113 +           
 α-actinin 103 +    +        
 major vault protein (MVP) 99 + +    +   + +   +  
 transitional endoplasmatic reticulum ATPase (TER ATPase) 89   +   +        
 integrin β1 88 + + +     + + + + +
 heat shock protein 90 (HSP90) 83 +    +    +     
 protein disulphide-isomerase A4 (PDIA4) 73 +           
 heat shock protein A5 (HSPA5) 72 + +          
 heat shock protein 70 (HSP70) 71 + + +     + +    
 moesin 68 + + 2D     + + +   +
 BSA (precursor) 66 +           
 galectin-3-binding protein (G3BP) 65        + + +   
 pyruvate kinase 62 +           
 gamma-glutamyltransferase (GGT) 61        +     
 glucose-6-phosphate 1-dehydrogenase 59 +           
 protein disulphide-isomerase A3 (PDIA3) 57 + 2D          
 aldehyde dehydrogenase 55 +           
 tubulin β 50 + +          
 tubulin α 50 + + 2D         +
 α-enolase 47 + 2D +         
 actin 42 + + +    + + + +   +
 MHC class I antigen 41        +     
 annexins A1,A2,A4,A5 39 + + + + + + + + + + +
 aldolase reductase 36 + 2D          
 glyceraldehyde 3-phosphate dehydrogenase (GAPDH) 36 +           
 ribosomal protein 40S SA 33 +           
 triosephosphate isomerase 31 + 2D 2D         
 ribosomal protein L7a 30   +          
 ribosomal protein 40S S4 30 +           
 clathrin light chain (LC) 27 +           
 chloride intracellular channel protein 27   +          
 galectin-3 26   2D      +     
 CD9, CD81 25          +   
 ras-related protein Rab 5 24        +     
 glutathione S-transferase (GST) 23 + 2D          
 ribosomal protein 40S S5 23 +           
 heat shock protein β1 (HSPβ1) 23 + + 2D     +    +  
 RhoA 22        +     
 peroxiredoxin 22 + 2D 2D         
 cyclophilin A (CypA) 18 + + +     + + +   +
 ubiquitin-ribosomal protein S27a 18 +   2D         
 ribosomal protein 40S S16 16 + +          
 ribosomal protein 40S S14 16 +           
 galectin-1 15 +   2D         
 profilin-1 15 +           
 histone H3 15 + + +        + +
 histone H2AX 15 + + +         
 β2-microglobulin 14 +           
 ribosomal protein 60S L30 13   +          
 S100-A11 12   2D      +     
 histone H4 11   + +        + +
 S100-A10 11        +     
  1. amolecular mass of a monomer is given
  2. 2D – indicates that the protein was detected in 2D gel electrophoresis of UC purified MEV (Table 1, sample C and Fig. 1(C)) or MUV (Table 1, sample (C) and Fig. 2(C)), but not when these samples were resolved only by SDS-PAGE (for further information see Additional file 1: Figure S6 & Table S1)