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Table 2 Fold change and replicative capacity of naturally occurring RASs in isolates retrieved from Los Alamos HCV database

From: Natural polymorphisms in the resistance associated sites of HCV-G1 NS5B domain and correlation with geographic origin of HCV isolates

RAS DRUGa HCV subtype Fold change Replicative capacity References
421 V BCV 1a 3 NAb
556G DSV 1a 30 59% [2]
556 N DSV 1a 29 NA
282 T SOF 1b 10 5% [3, 4]
159F SOF 1b 1.3 25% [3, 4]
316 N SOF 1b 1.6 154% [2]
  DSV   5 154% [2]
556G DSV 1b 11 62% [2]
445F DSV 1b 16 NA
499A DLV 1b 6 NA
  DSV 1b 1.4 NA
  1. aBCV beclabuvir, DSV dasabuvir, SOF sofosbuvir, DLV deleobuvir bNA not available