Natural polymorphisms in the resistance associated sites of HCV-G1 NS5B domain and correlation with geographic origin of HCV isolates

Table 2 Fold change and replicative capacity of naturally occurring RASs in isolates retrieved from Los Alamos HCV database

RAS	DRUG^a	HCV subtype	Fold change	Replicative capacity	References
421 V	BCV	1a	3	NA^b	–
556G	DSV	1a	30	59%	[2]
556 N	DSV	1a	29	NA	–
282 T	SOF	1b	10	5%	[3, 4]
159F	SOF	1b	1.3	25%	[3, 4]
316 N	SOF	1b	1.6	154%	[2]
	DSV		5	154%	[2]
556G	DSV	1b	11	62%	[2]
445F	DSV	1b	16	NA	–
499A	DLV	1b	6	NA	–
	DSV	1b	1.4	NA	–

^aBCV beclabuvir, DSV dasabuvir, SOF sofosbuvir, DLV deleobuvir ^bNA not available

ISSN: 1743-422X