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Table 3 Implications of Drug Resistance Associated Mutations Detected

From: Emergence of HIV-1 drug resistance mutations in mothers on treatment with a history of prophylaxis in Ghana

HIV-1 Drug status Mutations Drug resistance Useful drug options
NRTI
 Art after prophylaxis M184 V 3TC,FTC,DDI,ABC AZT,TDF D4T
M184 V,M41 L,T215Y ABC,AZT,D4T,DDI, TDF,3TC,FTC NONE
M184 V,M41 L,L74 V, T215Y ABC,AZT,DDI, 3TC,FTC
 Art no prophylaxis M184 V,D67G,M41 LM, K70R,K219E,T215I 3TC,AZT,FTC,ABC, D4T,DDI,TDF NONE
M184 V 3TC,FTC,DDI,ABC AZT,TDF,D4T,
M184 V,Y115F,T215S ABC,TDF 3TC,FTC,DDI
 Drug-naive M184 V 3TC,ABC,DDI,FTC AZT,D4T,TDF
L210 W AZT,ABC,DDI,FTC, TDF 3TC
NNRTI
 Art after prophylaxis K103 N,Y181C NVP,EFV,ETR,RPV NONE
A98G,K103 N,M230 LM NVP,EFV,ETR,RPV NONE
K103 N,M230 L,L100IL, A98G NVP,EFV,ETR,RPV NONE
 Art no prophylaxis A98G NVP EFV
 Drug-naive K103 N NVP,EFV NONE
V106A NVP,EFV NONE
E138A NVP,EFV,ETR,RPV NONE
A98G NVP EFV
  1. NRTI Nucleoside Reverse Transcriptase Inhibitors, NNRTI Non-Nucleoside Reverse Transcriptase Inhibitors