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Fig. 6 | Virology Journal

Fig. 6

From: A loop-mediated isothermal amplification assay for the detection and quantification of JC polyomavirus in cerebrospinal fluid: a diagnostic and clinical management tool and technique for progressive multifocal leukoencephalopathy

Fig. 6

Changes in the JCV genome copy number in CSF in sequential samples. Underlying diseases and condition of eight PML patients (#1 to #8) are as follows: two patients had HIV/AIDS (#1 and #2) and received antiretroviral therapy (HAART) after the first CSF sampling and four had hematologic disorders (acute lymphoblastic leukemia with bone marrow transplantation (#3), chronic lymphocytic leukemia (#4), acute myeloid leukemia with umbilical cord blood transplantation (#5), and primary macroglobulinemia (#6)), one had an autoimmune disorder (systemic lupus erythematosus) (#7), and one had hepatitis C virus-related liver disease (#8). Circles show the JCV genome copy numbers, as determined by the LAMP assay, and squares show those determined by the qPCR assay. Asterisk indicates the sample which showed LAMP-positive but the viral genome copy number was lower than cut off value in the LAMP quantification. Days counted from the first CSF sampling date. ND, not detected

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