Skip to main content

Table 3 A summary of results of histopathologic lesions in mice inoculated orally with a low or high dose of ncp BVDV-2 determined by IHC

From: Experimental infection of mice with noncytopathic bovine viral diarrhea virus 2 increases the number of megakaryocytes in bone marrow

Day

Day 2

Day 5

Day 9

L1

L2

L3

L4

H1

H2

H3

H4

L1

L2

L3

L4

H1

H2

H3

H4

L1

L2

L3

L4

H1

H2

H3

H4

Tissues

Lympholysis in Peyer’s patches

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

+

Lympholysis in the spleen

+

+

+

+

+

+

+

+

+

+

+

Inflammatory cells infiltration in the spleen

+

+

+

+

+

+

+

+

+

+

++

++

+

+

++

+

+

++

+

+

++

  1. Eight mice were euthanized at each time point. Four mice were inoculated with a low dose, and four were inoculated with a high dose of the virus. Three independent experiments were conducted, and the results were the same. The data are representative of three independent experiments
  2. L: low dose (4 × 105 TCID50); H: high lose (1.2 × 106 TCID50)
  3. “−”: no lesion, “+”: mild lesions, “++”: moderate lesions