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Table 3 Prior distribution estimates and Bayesian posterior distribution estimates for IgM sensitivities and specificities of the assays

From: Enzyme-linked immunosorbent assay using recombinant envelope protein 2 antigen for diagnosis of Chikungunya virus

  Prior distribution estimate Posterior distribution estimate
Mode ULa LLb Beta Median 95% PI
Sensitivity
 rE2-CHIKV ELISA 0.9285   0.90 100, 8.623 0.9248 0.8671–0.9638
 EIA-ICC 0.4260 0.75   1.235, 1.317 0.7401 0.4345–0.9478
 Commercial Assay 0.9231   0.90 100, 9.247 0.9131 0.9131–0.9574
Specificity
 rE2-CHIKV ELISA 0.9665   0.90 26.541, 1.885 0.7904 0.6841–0.8793
 EIA-ICC 0.9850   0.90 18.876, 1.272 0.5559 0.4340 - 0.6740
 Commercial Assay 0.9411   0.90 55.179, 4.391 0.9421 0.8829–0.9788
  1. aUL (upper limit): value considered (with 95% confidence) to be the highest possible value for that parameter
  2. bLL (lower limit): value considered (with 95% confidence) to be the lowest possible value for that parameter