Skip to main content

Table 3 TNF-α, IFN-γ, and IL-2 protein expression in the liver

From: Immunogenicity of adenovirus-vector vaccine targeting hepatitis B virus: non-clinical safety assessment in non-human primates

  Staining Groups
Vehicle control Low-dose Mid-dose High-dose Ad-null
TNF-α Low (%) 4 (40%) 3(30%) 2 (20%) 4 (40%) 5 (50%)
High (%) 6 (60%) 7(70%) 8 (80%) 6 (60%) 5 (50%)
IFN-γ Low (%) 10 (100%) 10 (100%) 5 (50%) 4 (40%) 5 (50%)
High (%) 0(0%) 0 (0%) 5 (50%)*# 6 (60%)*# 5 (50%)*#
IL-2 Low (%) 8(80%) 7 (70%) 1 (10%) 3 (30%) 3 (30%)
High (%) 2(20%) 3 (30%) 9 (90%)*# 7 (70%)*# 7 (70%)*#
  1. *and #p < 0.05 compared with the vehicle control or low-dose group, respectively