Differences in genome characters and cell tropisms between two chikungunya isolates of Asian lineage and Indian Ocean lineage

Table 1 Amino acid mutations in SZ1239 and SZ1050 compared with S27

Protein	SZ1239	SZ1050
nsP1	P3S, P34S, L172 V, E234K,K253 M,M383 L, I384L,S454G,S473R,T478A,T481I, D486N, R491Q, L507H	T128 K, L172 V, R221S, G230R,E234K,T376 M, M383 L, I384L, T481I, Q488R,L507R
nsP2	P16L, T218S, Q273L, K338 M, M466 V, I486V, C642Y, S643 N, V756I, N768S	S14 N,H374Y,S643 N,A793V
nsP3	V166I, M213 V,Y217H, S283 N, P326S, Q332R, A334V, T336 M, V339A, K342E, I343T,377–383 gap T413 V,L434Q,V437A, M449I, Q452R,T459 V,N483D, E484D, R524G,	V175I,Y217H, P326S, V331A, T337I, A383T, I377T, K352E,L460P, S461 N, P471S
nsP4	A43L, M58 T, R85K, S90A, I101V, Y107H, Q235R, K271R, E280D, T366A, I514T, V555I,V582A, V604I	I75V, T254A, I514T, Q500L,V555I, V604I
C	Q37K, A55V, Q78R, T81 M,A93V	P23S,V27I,K63R
E3	T23I, S44R, R60H	I23T,V42I,P59S
E2	I2T, H5N, K57G, M74I, G79E,S118G, K149R,V157A, N160 T, L181 M,G205D,N207S, I211T, L248S,I255V,M267R,S299 N,Q307R, V317I, V318R, A344T,V370A,M384 V	G57 K, I74M,G79E,N160 T, A164I, L181 M, S194G, I211T,V264A, M267R, S299 N,T312 M, A344T, S375 T,V386A
6 K	T45 M,A47T, M52 L, I54V	V8I,I54V
E1	N72S,A98T, T145A, K211E, A225S, P304S, A321T, V322A, L397P	K211E, M269 V, D284E, V322A

ISSN: 1743-422X