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Table 1 Cytotoxicity and antiviral activity of quercetin against enterovirus 71 (EV71)

From: Inhibition of enterovirus 71 replication and viral 3C protease by quercetin

Cell types

Quercetin

Ribarivina

EC50b (μM)

CC50c (μM)

SId

EC50 (μM)

CC50 (μM)

SI

RD

12.1e±3.6

>200

>16.6

34.5±3.1

>200

>5.8

Vero

8.8±2.2

>200

>22.8

42.8±6.8

>200

>4.7

  1. aRibavirin, used as a positive control
  2. bEC50: compound concentration required to achieve 50% protection from virus-induced cytopathogenicity
  3. cCC50: compound concentration required to reduce cell viability by 50%
  4. dSI (selectivity index): ratio by CC50/EC50
  5. eValues represent the mean ± SD of three independent experiments