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Fig. 4 | Virology Journal

Fig. 4

From: Trigger factor assisted self-assembly of canine parvovirus VP2 protein into virus-like particles in Escherichia coli with high immunogenicity

Fig. 4

Analysis of cytokine production secreted from the spleen lymphocytes of guinea pigs. Spleens of guinea pigs from each group were removed at 42 dpi. The culture supernatants of cells stimulated by CPV were collected after 72 h and detected by ELISA kits. a the concentration of guinea pig IFN-γ in each group. b the concentration of guinea pig IL-4 in each group. The values are expressed as means ± SEM. The statistical significance of cytokine concentration differences between vaccinated and PBS control guinea pigs were analyzed by one-way ANOVA statistical analysis (*p < 0.05, **p < 0.01, and ***p < 0.001)

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