Fig. 1

Schematic representation of MACV wt and r3MACV genomic constructs. Arenaviruses have a bisegmented negative single-stranded RNA genome. a For the MACV wt, the S segment encodes the viral glycoprotein precursor (GPC) and the nucleoprotein (NP), whereas L segment encodes the viral polymerase (L) and the small RING finger protein Z. b For the r3MACV, one S segment encodes the MACV GPC and the GTOV GPCΔ33, and the other encodes the CHAPV GPCΔ33 and the MACV NP, and the L segment is unchanged than the wt genome. Mutations inserted in r3MACV genome were noted