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Fig. 4 | Virology Journal

Fig. 4

From: Zika virus-induced hyper excitation precedes death of mouse primary neuron

Fig. 4

Zika virus (ZIKV) effects on primary neuron networks from at 3 dpi. a Representative confocal images showing DAPI marker (blue), NeuN antibody (red), and MAP2 antibody (turquoise) at the top and its corresponding images with MAP2 staining below. Image analysis with ImageJ software reveals the differences of MAP2 signaling. b Quantification of MAP2 coverage, normalized by the number of DAPI counts in mouse primary neuron cultures at 3 dpi, n values are detailed in Additional file 2: Table S2. c Bar plots compare the size of DAPI stained nuclei of ZIKV infected and uninfected cells at 3 dpi. Each bin represents the distribution range size of nuclei in square pixel (n = 5 images for each condition). Bar plot values are shown with ± Standard Error of the Mean (SEM) with Mann-Whitney p-value on top, *P < 0.05; **P < 0.01; ***P < 0.001. On the right, confocal pictures illustrating nuclei sizes at 3 dpi

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