Table 3 Description of the samples that underwent changes in their amino acids, the type of exchange, location of the exchange site, description of the domain and signs / symptoms and / or diseases associated with HTLV-1
Patient | Amino acid mutation of the gp46 gene | Domain/Site | Description of the domain | Signs/Symptoms/Diseases associated with the HTLV-1 |
|---|---|---|---|---|
2443 | S192P a | 175-209aa/ 181-208aa | Region dominated by linear epitopes/ funcional domain | Scaly lesions |
285 | S192P a | 175-209aa/ 181-208aa | Region dominated by linear epitopes/ funcional domain | Ophthalmological problems, pain, dysautonomia, motor disorder |
2454 | S192Pa/ S194 T/ L200H/ L210H/ L213P | 175-209aa/ 181-208aa/ 197-205aa | Region dominated by linear epitopes/ funcional domain/ funcional domain | Asymptomatic |
762 | S192P a | 175-209aa/ 181-208aa | Region dominated by linear epitopes/ funcional domain | Asymptomatic |
2300 | S72G a | 25-190aa/ 53-75aa | Receptor Binding Domain (RBD)/ Region dominated by linear epitopes | Asymptomatic |
729 | S72G a | 25-190aa/ 53-75aa | Receptor Binding Domain (RBD)/ Region dominated by linear epitopes | Asymptomatic |
1638 | S72G a | 25-190aa/ 53-75aa | Receptor Binding Domain (RBD)/ Region dominated by linear epitopes | HAM/TSP |
2452 | S72G a | 25-190aa/ 53-75aa | Receptor Binding Domain (RBD)/ Region dominated by linear epitopes | Sensitivity and pain |
558 | S35 L | 25-190aa | Receptor Binding Domain (RBD) | Asymptomatic |
1569 | N93D a | 25-190aa/ 53-75aa/ 75-101aa/ 86-107aa/ 90-94aa | Receptor Binding Domain (RBD)/ Region dominated by linear epitopes/ funcional domain/Region dominated by linear epitopes/Amino acid associated with neuropilin 1. | Sensitivity and pain |
2422 | N93D a | 25-190aa/ 53-75aa/ 75-101aa/ 86-107aa/ 90-94aa | Receptor Binding Domain (RBD)/ Region dominated by linear epitopes/ funcional domain/Region dominated by linear epitopes/Amino acid associated with neuropilin 1. | Sensitivity and pain |
331 | N93D a | 25-190aa/ 53-75aa/ 75-101aa/ 86-107aa/ 90-94aa | Receptor Binding Domain (RBD)/ Region dominated by linear epitopes/ funcional domain/Region dominated by linear epitopes/Amino acid associated with neuropilin 1. | Sensitivity and pain |
1564 | N93D a | 25-190aa/ 53-75aa/ 75-101aa/ 86-107aa/ 90-94aa | Receptor Binding Domain (RBD)/ Region dominated by linear epitopes/ funcional domain/Region dominated by linear epitopes/Amino acid associated with neuropilin 1. | Sensitivity and pain |
1571 | N93D a | 25-190aa/ 53-75aa/ 75-101aa/ 86-107aa/ 90-94aa | Receptor Binding Domain (RBD)/ Region dominated by linear epitopes/ funcional domain/Region dominated by linear epitopes/Amino acid associated with neuropilin 1. | Sensitivity, pain, infection with the parasite S. stercoralis/HIV+ |
293 | L163I | 25-190aa | Receptor Binding Domain (RBD) | Sensitivity, pain, and motor disorder |
1588 | S38 N | 25-190aa | Receptor Binding Domain (RBD) | Sensitivity and pain |
2446 | C26S/ S72Ga | 25-190aa/ 53-75aa | Receptor Binding Domain (RBD)/ Region dominated by linear epitopes | Sensitivity, pain, dysautonomia, motor disorder, infection by S. stercoralis |
937 | L70I/ S103P | 25-190aa/ 53-75aa/ 86-107aa | Receptor Binding Domain (RBD)/ Region dominated by linear epitopes/Region dominated by linear epitopes | HAM/TSP |
1276 | I150V/ L219I | 25-190aa | Receptor Binding Domain (RBD) | Sensitivity and pain |
857 | F14S | Location not described | Domain not described | Asymptomatic |
1367 | N24H | Location not described | Domain not described | Asymptomatic |