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Table 3 Description of the samples that underwent changes in their amino acids, the type of exchange, location of the exchange site, description of the domain and signs / symptoms and / or diseases associated with HTLV-1

From: Stability of the HTLV-1 glycoprotein 46 (gp46) gene in an endemic region of the Brazilian Amazon and the presence of a significant mutation (N93D) in symptomatic patients

Patient Amino acid mutation of the gp46 gene Domain/Site Description of the domain Signs/Symptoms/Diseases associated with the HTLV-1
2443 S192P a 175-209aa/ 181-208aa Region dominated by linear epitopes/ funcional domain Scaly lesions
285 S192P a 175-209aa/ 181-208aa Region dominated by linear epitopes/ funcional domain Ophthalmological problems, pain, dysautonomia, motor disorder
2454 S192Pa/ S194 T/ L200H/ L210H/ L213P 175-209aa/ 181-208aa/ 197-205aa Region dominated by linear epitopes/ funcional domain/ funcional domain Asymptomatic
762 S192P a 175-209aa/ 181-208aa Region dominated by linear epitopes/ funcional domain Asymptomatic
2300 S72G a 25-190aa/ 53-75aa Receptor Binding Domain (RBD)/ Region dominated by linear epitopes Asymptomatic
729 S72G a 25-190aa/ 53-75aa Receptor Binding Domain (RBD)/ Region dominated by linear epitopes Asymptomatic
1638 S72G a 25-190aa/ 53-75aa Receptor Binding Domain (RBD)/ Region dominated by linear epitopes HAM/TSP
2452 S72G a 25-190aa/ 53-75aa Receptor Binding Domain (RBD)/ Region dominated by linear epitopes Sensitivity and pain
558 S35 L 25-190aa Receptor Binding Domain (RBD) Asymptomatic
1569 N93D a 25-190aa/ 53-75aa/ 75-101aa/ 86-107aa/ 90-94aa Receptor Binding Domain (RBD)/ Region dominated by linear epitopes/ funcional domain/Region dominated by linear epitopes/Amino acid associated with neuropilin 1. Sensitivity and pain
2422 N93D a 25-190aa/ 53-75aa/ 75-101aa/ 86-107aa/ 90-94aa Receptor Binding Domain (RBD)/ Region dominated by linear epitopes/ funcional domain/Region dominated by linear epitopes/Amino acid associated with neuropilin 1. Sensitivity and pain
331 N93D a 25-190aa/ 53-75aa/ 75-101aa/ 86-107aa/ 90-94aa Receptor Binding Domain (RBD)/ Region dominated by linear epitopes/ funcional domain/Region dominated by linear epitopes/Amino acid associated with neuropilin 1. Sensitivity and pain
1564 N93D a 25-190aa/ 53-75aa/ 75-101aa/ 86-107aa/ 90-94aa Receptor Binding Domain (RBD)/ Region dominated by linear epitopes/ funcional domain/Region dominated by linear epitopes/Amino acid associated with neuropilin 1. Sensitivity and pain
1571 N93D a 25-190aa/ 53-75aa/ 75-101aa/ 86-107aa/ 90-94aa Receptor Binding Domain (RBD)/ Region dominated by linear epitopes/ funcional domain/Region dominated by linear epitopes/Amino acid associated with neuropilin 1. Sensitivity, pain, infection with the parasite S. stercoralis/HIV+
293 L163I 25-190aa Receptor Binding Domain (RBD) Sensitivity, pain, and motor disorder
1588 S38 N 25-190aa Receptor Binding Domain (RBD) Sensitivity and pain
2446 C26S/ S72Ga 25-190aa/ 53-75aa Receptor Binding Domain (RBD)/ Region dominated by linear epitopes Sensitivity, pain, dysautonomia, motor disorder, infection by S. stercoralis
937 L70I/ S103P 25-190aa/ 53-75aa/ 86-107aa Receptor Binding Domain (RBD)/ Region dominated by linear epitopes/Region dominated by linear epitopes HAM/TSP
1276 I150V/ L219I 25-190aa Receptor Binding Domain (RBD) Sensitivity and pain
857 F14S Location not described Domain not described Asymptomatic
1367 N24H Location not described Domain not described Asymptomatic
  1. (a: The amino acid changes with the highest frequencies in the samples) Source: Study protocol, 2017.