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Fig. 4 | Virology Journal

Fig. 4

From: Genotype-specific and cross-reactive neutralizing antibodies induced by dengue virus infection: detection of antibodies with different levels of neutralizing activities against homologous and heterologous genotypes of dengue virus type 2 in common marmosets (Callithrix jacchus)

Fig. 4

Neutralizing antibodies titers to DENV-2 genotypes (Cosmopolitan, Asian I and Asian/American) after tertiary inoculation. a Marmosets which had been first inoculated with DENV-2 16,881 PDK-53 (Asian I genotype) and then challenged with DENV-2 genotype Cosmopolitan were infected with DENV-1 in tertiary inoculation. b Neutralizing antibody titers to DENV-1, genotype 1 in the same marmosets in (a). c Marmosets that were first inoculated with the DENV-2 Asian I genotype and then challenged with the DENV-2 genotype Cosmopolitan were infected with DENV-1 genotype I in tertiary inoculation. d Neutralizing antibody titers to DENV-1, genotype 1 in the same marmosets in (c). Double asterisks (**) indicate that there were statistically significant differences (p < 0.05) in the titers of neutralizing antibodies between genotypes. Student’s test analysis was used to determine the differences in mean titers of neutralizing antibody between CM vs AI, CM vs AA, and AI vs AA. CM indicates Cosmopolitan genotype. A1 indicates Asian I genotype. AA indicates Asian/American genotype

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Virology Journal

ISSN: 1743-422X