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Fig. 3 | Virology Journal

Fig. 3

From: Genotype-specific and cross-reactive neutralizing antibodies induced by dengue virus infection: detection of antibodies with different levels of neutralizing activities against homologous and heterologous genotypes of dengue virus type 2 in common marmosets (Callithrix jacchus)

Fig. 3

Neutralizing antibodies titers to DENV-2 genotypes (Cosmopolitan, Asian I and Asian/American) in marmosets inoculated with candidate dengue vaccines and challenged with isolated DENV. Neutralizing antibody titers in marmosets inoculated with: a Candidate vaccine DENV-2 16,881 PDK-53, b Candidate vaccine DENV-2 16,881 PDK-53 in primary and with DENV-2 genotype Cosmopolitan in secondary, c Vaccine candidate DENV-1 16,007 PDK-13, d Vaccine candidate DENV-1 16,007 PDK-13 in primary and DENV-1 genotype I in secondary. Double asterisks (**) indicate that there were statistically significant differences (p < 0.05) in the titers of neutralizing antibodies between genotypes. Student’s test analysis was used to determine the differences in mean titers of neutralizing antibody between CM vs AI, CM vs AA, and AI vs AA. CM indicates Cosmopolitan genotype. A1 indicates Asian I genotype. AA indicates Asian/American genotype

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Virology Journal

ISSN: 1743-422X