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Fig. 2 | Virology Journal

Fig. 2

From: Genotype-specific and cross-reactive neutralizing antibodies induced by dengue virus infection: detection of antibodies with different levels of neutralizing activities against homologous and heterologous genotypes of dengue virus type 2 in common marmosets (Callithrix jacchus)

Fig. 2

Neutralizing antibodies titers to DENV-2 genotypes (Cosmopolitan, Asian I and Asian/American) after secondary DENV inoculation. Neutralizing antibody titers in marmosets inoculated with: a Homologous DENV-2 genotype(Cosmopolitan), b Heterologous DENV-2 genotypes (Asian1 in primary, Cosmopolitan in secondary), c two DENV-1 genotypes (Genotype 1 in primary, Genotype II in secondary), d Neutralizing antibody titers to DENV-1 genotype I during two DENV-1 genotypes (Genotype 1 in primary, Genotype II in secondary), e Heterologous serotypes (DENV-2 Asian1 genotype in primary, DENV-1 Genotype 1 in secondary), f Neutralizing antibody titers to DENV-1 genotype I after inoculation with heterologous serotypes (DENV-2 Asian1 genotype in primary, DENV-1 Genotype 1 in secondary). Double asterisks (**) indicates that there were statistically significant differences (p < 0.05) in the titers of neutralizing antibodies between genotypes. Student’s test analysis was used to determine the differences in mean titers of neutralizing antibody between CM vs AI, CM vs AA, and AI vs AA. Neutralizing antibody data at day 365 post-inoculation of (b) are the same data as day0 of Fig. 4b. CM indicates Cosmopolitan genotype, A1 indicates Asian I genotype and AA indicates Asian/American genotype

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