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Table 1 Growth on receptor-deficient cells and neutralization profiles of A24 Cruzeiro and O1 Manisa and their derivatives

From: Influence of cell type and cell culture media on the propagation of foot-and-mouth disease virus with regard to vaccine quality

Virus isolate Cell line VNT
CHO-K1 CHO677 Serum titer r1-value
A24 Cruzeiro 2.8 ± 0.2 negative 3.4 ± 0.2  
A24–179 2.3 ± 0.3 negative 3.6 ± 0.2 1.05
A24-2P 4.0 ± 0.4 2.5 ± 0.6 3.5 ± 0.1 1.02
O1 Manisa 2.8 ± 0.1 negative 3.2 ± 0.1  
O1–179 2.0 ± 0.1 negative 3.5 ± 0.2 1.09
O1-2P 1.9 ± 0.2 negative 3.4 ± 0.1 1.06
  1. Values represent mean virus and neutralization titers and standard deviations, shown as log10 infectious or neutralizing doses per milliliter. The r1-value was calculated by dividing the neutralization titer against the adapted isolate by the neutralization titer against the original virus isolate